Multicomponent synthesis and photophysical study of novel α,β-unsaturated carbonyl depsipeptides and peptoids

Multicomponent reactions were performed to develop novel α,β-unsaturated carbonyl depsipeptides and peptoids incorporating various chromophores such as cinnamic, coumarin, quinolines. Thus, through the Passerini Ugi multicomponent (P-3CR U-4CR), we obtained thirteen in moderate high yield following established protocol fundamentally varying electron-rich carboxylic acid reactants. UV/Vis spectroscopy was utilized study photophysical properties of newly synthesized compounds. Differences between carbonyl-substituted cause differences electron delocalization that can be captured spectra. The near UV regions all compounds exhibited strong absorption bands. Compounds P2 , P5 U2 U5 U7 displayed bands range 250–350 nm, absorbing radiation this broad region electromagnetic spectrum. A photostability for showed its molecular structure does not change after exposure radiation. Fluorescence analysis an incipient emission while U6 blue fluorescence under electronic also determined by TD-DFT theoretical study.